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Multiple Choice

Which tests are among FDA required sero tests?

The main idea is that FDA-required donor screening uses a broad mix of tests to detect the main transfusion-transmissible infections, using both antibody/antigen tests and nucleic acid testing to catch infections early and reliably. The best choice lists HIV antibody testing along with HIV/HCV nucleic acid testing, HBV nucleic acid testing, HCV antibody testing, total hepatitis B core antibody, and syphilis testing. This combination reflects the kinds of screens FDA expects: detecting HIV and HCV exposure (antibody tests), catching active infections with NAT for HIV, HBV, and HCV, identifying past HBV exposure with core antibody, and screening for syphilis. It covers the broad safety net needed for donor blood. Choosing only HIV testing, or only HCV RNA, or only HBsAg would miss other important infections and would not meet the full screening requirements.

The main idea is that FDA-required donor screening uses a broad mix of tests to detect the main transfusion-transmissible infections, using both antibody/antigen tests and nucleic acid testing to catch infections early and reliably.

The best choice lists HIV antibody testing along with HIV/HCV nucleic acid testing, HBV nucleic acid testing, HCV antibody testing, total hepatitis B core antibody, and syphilis testing. This combination reflects the kinds of screens FDA expects: detecting HIV and HCV exposure (antibody tests), catching active infections with NAT for HIV, HBV, and HCV, identifying past HBV exposure with core antibody, and screening for syphilis. It covers the broad safety net needed for donor blood.

Choosing only HIV testing, or only HCV RNA, or only HBsAg would miss other important infections and would not meet the full screening requirements.