Which of the following is NOT a PKP contraindication?

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Multiple Choice

Which of the following is NOT a PKP contraindication?

In penetrating keratoplasty, tissue is chosen based on how well the donor cornea will perform, not just the donor’s past history. What matters most is the quality and safety of the corneal tissue: clear stroma, healthy endothelium, and no active infection or disease processes. Corneas from patients who had anterior segment surgery are not automatically excluded. If the tissue is thoroughly screened and meets criteria for clarity, endothelial cell health, and absence of infection, it can be used. That’s why this option is the one that is not a contraindication. The other scenarios describe tissue that would raise problems for graft success. A donor cornea with a central pterygium would interfere with optical quality and graft outcomes. A donor from someone with Down syndrome is listed as a contraindication in this context, likely due to associated ocular or systemic factors that could complicate the transplant. A donor with a history of intraocular or anterior segment surgery likewise raises concerns about tissue quality or hidden pathology, making it a contraindication. So, the only non‑contraindicated option is corneas from patients who had anterior segment surgery if they pass the required screening.

In penetrating keratoplasty, tissue is chosen based on how well the donor cornea will perform, not just the donor’s past history. What matters most is the quality and safety of the corneal tissue: clear stroma, healthy endothelium, and no active infection or disease processes.

Corneas from patients who had anterior segment surgery are not automatically excluded. If the tissue is thoroughly screened and meets criteria for clarity, endothelial cell health, and absence of infection, it can be used. That’s why this option is the one that is not a contraindication.

The other scenarios describe tissue that would raise problems for graft success. A donor cornea with a central pterygium would interfere with optical quality and graft outcomes. A donor from someone with Down syndrome is listed as a contraindication in this context, likely due to associated ocular or systemic factors that could complicate the transplant. A donor with a history of intraocular or anterior segment surgery likewise raises concerns about tissue quality or hidden pathology, making it a contraindication.

So, the only non‑contraindicated option is corneas from patients who had anterior segment surgery if they pass the required screening.

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